"Once upon a time, a skinny kid from New York City picked up a shield and charged into battle… a prodigal son lifted a sacred hammer and proved himself worthy… and an arrogant genius forged an armor that would harness his true potential. And together, they became Earth’s Mightiest Heroes. Today, that heroic legacy lives on in the next generation of heroes – and it will be put to the test as the Marvel Universe’s greatest champions unite and charge headlong into tomorrow!"
The series consists of a ten issue anthology featuring a team-up of different incarnations of ten different superheroes and is scheduled to run from August to September 2017. Despite the fact that at the time of publication some of the characters listed in the pairings were either dead or incapacitated, Marvel Editor-in-Chief Axel Alonso insisted that the series does not take place in an alternate timeline explaining, "These stories do happen, they really count. They really matter. This isn't some alternate reality story or some time-travel story." Alonso added, "You don't take these characters off the board with the intention to keep them off the board forever. One of the tropes of our medium is characters get a second wind. They die and come back. That's part of the beauty of what we do."
Alonso stated that the ten pairings should "illuminate who they are and indicate where they will be moving in the future." For instance, Brian Michael Bendis writer of the Iron Man and Spider-Man issues said Tony Stark could have a lasting influence on Riri Williams because "[she] is at the most impressionable stage of her life," while Peter Parker and Miles Morales, despite being from different backgrounds, have a "spiritual connection" that allowed him to examine the Spider-Man mantra of "with great power, must come great responsibility" from different perspectives. G. Willow Wilson writer of the Ms. Marvel said Carol Danvers and Kamala Khan have a mentor–student relationship, but "at its heart, Ms. Marvel is about growing up, and a big part of growing up is discovering that your idols have feet of clay – and forgiving them for their flaws as you gain an adult understanding of your own." Tom Taylor writer of Wolverine said, "Being alongside Logan will only strengthen Laura's resolve to be the best there is at what she does... She's ready to show what else her claws can do. She's ready to step away from her violent past and use her claws for good."
Generations: The Iron Tony Stark and Riri Williams Brian Michael Bendis (W) and Marco Rudy (A)
Generations: The Spiders Peter Parker and Miles Morales Brian Michael Bendis (W) and Ramon Perez (A)
Generations: The Marvels Carol Danvers and Kamala Khan G. Willow Wilson (W) and Paolo Villanelle (A)
Generations: The Thunder Odinson and Jane Foster Jason Aaron (W) and Mahmud Asrar (A)
Generations: The Archers Clint Barton and Kate Bishop Kelly Thompson (W) and Stefano Raffaele (A)
Generations: The Strongest Bruce Banner and Amadeus Cho Greg Pak (W) and Matteo Buffagni (A)
Generations: The Phoenix Jean Grey (young and older) Dennis Hopeless (W) and RB Silva (A)
Generations: The Best Logan and X-23 Tom Taylor (W) and Ramon Rosanas (A)
Generations: The Bravest Mar-Vell and Carol Danvers Margaret Stohl (W) and Brent Schoonover (A)
Generations: The Americas Steve Rogers and Sam Wilson Nick Spencer (W) and Paul Renaud (A)